{"id":1461,"date":"2021-06-08T14:57:22","date_gmt":"2021-06-08T17:57:22","guid":{"rendered":"https:\/\/petrusraulino.com.br\/?p=1461"},"modified":"2024-11-11T17:20:03","modified_gmt":"2024-11-11T20:20:03","slug":"epigenetic-effects-induced-by-mood-stabilizers-in-schizophrenia-and-affective-disorders","status":"publish","type":"post","link":"https:\/\/petrusraulino.com.br\/en\/epigenetic-effects-induced-by-mood-stabilizers-in-schizophrenia-and-affective-disorders\/","title":{"rendered":"Epigenetic effects induced by mood stabilizers in schizophrenia and affective disorders"},"content":{"rendered":"

By Dr. Petrus Raulino<\/strong><\/em><\/p>\n

Research published in the journal <\/span>Frontiers in Pharmacology<\/span><\/i> and carried out by the Department of Psychiatry and Psychology of the <\/span>Mayo Clinic<\/span><\/i> presented a systematic review of studies investigating epigenetic alterations induced by non-antipsychotic mood stabilizers (valproate, lithium, lamotrigine and carbamazepine).<\/span><\/p>\n

The review looked for scientific articles with animal models, human cell lines and people with Bipolar disorder<\/a>, Schizophrenia<\/a> e Major Depressive Disorder<\/a>.<\/span><\/p>\n

The epigenome<\/h2>\n

Knowing the epigenome - the dynamics that determine gene expression - allows us to better understand how genes work. <\/span>The epigenome responds to environmental signals by \"turning on\" or \"turning off\" the activity of genes.<\/span><\/p>\n

Epigenetic alterations involve reversible chromatin rearrangements that induce mitotically heritable, stable, long-term and reversible gene expression patterns without altering the DNA sequence.<\/span><\/p>\n

A DNA methylation<\/a> and histone modifications are the most studied epigenetic marks in physiological and pathological contexts.<\/span><\/p>\n

Under physiological circumstances, epigenetic mechanisms control neurobiological processes, but deregulation of these mechanisms can translate into an increased risk of developing disease.<\/span><\/p>\n

Epimutations secondary to gene-environment interactions have been described as playing a fundamental role in the pathophysiology of the main psychiatric disorders, since genetic material can respond to modifications in environmental conditions.<\/span><\/p>\n

Despite the genetic complexity of mental disorders, evidence suggests that the epigenome can be modified by mood stabilizers, potentially translating into long-term changes in the evolution of the disorder.<\/span><\/p>\n

Conclusion of the research<\/h2>\n

The review concluded that the available scientific data confirms the effects of valproate and lithium on the epigenome of genes associated with psychiatric disorders through different mechanisms, particularly DNA methylation and histone acetylation.<\/span><\/p>\n

The review suggested that lamotrigine and carbamazepine may play a greater role in activating epigenetic mechanisms than the small number of studies with these drugs seems to suggest.<\/span><\/p>\n

A more advanced understanding of drug-induced epigenetic changes could facilitate personalized interventions in the future.<\/span><\/p>\n

 <\/p>\n

References<\/strong><\/h4>\n

Gardea-Resendez, M., Kucuker, M. U., Blacker, C. J., Ho, A. M. C., Croarkin, P. E., Frye, M. A., & Veldic, M. (2020). Dissecting the epigenetic changes induced by non-antipsychotic mood stabilizers on schizophrenia and affective disorders: a systematic <\/span>review.\u00a0<\/span>Frontiers in pharmacology<\/span><\/i>,\u00a0<\/span>11<\/span><\/i>, 467.<\/span><\/p>\n

Esteller, M. (2006). The necessity of a human epigenome project. <\/span>Carcinogenesis<\/span><\/i>, 27(6), 1121-1125.<\/span><\/p>","protected":false},"excerpt":{"rendered":"

Por Dr. Petrus Raulino Uma pesquisa publicada na revista Frontiers in Pharmacology e realizada pelo Departamento de Psiquiatria e Psicologia da Mayo Clinic apresentou uma revis\u00e3o sistem\u00e1tica de estudos que investigaram altera\u00e7\u00f5es epigen\u00e9ticas induzidas por estabilizadores de humor n\u00e3o antipsic\u00f3ticos (valproato, l\u00edtio, lamotrigina e carbamazepina). A revis\u00e3o buscou artigos cient\u00edficos com modelos animais, linhagens celulares […]<\/p>","protected":false},"author":4,"featured_media":1481,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_joinchat":[],"footnotes":""},"categories":[115,107,121,117,129],"tags":[],"class_list":["post-1461","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informativo","category-medicamentos","category-saude-mental","category-transtornos-psicologicos","category-tratamentos"],"yoast_head":"\nEfeitos epigen\u00e9ticos induzidos por estabilizadores na esquizofrenia<\/title>\n<meta name=\"description\" content=\"Pesquisa apresenta uma revis\u00e3o sistem\u00e1tica de estudos que investigaram altera\u00e7\u00f5es epigen\u00e9ticas induzidas por estabilizadores de humor.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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