{"id":1459,"date":"2021-06-08T14:55:36","date_gmt":"2021-06-08T17:55:36","guid":{"rendered":"https:\/\/petrusraulino.com.br\/?p=1459"},"modified":"2024-11-11T17:20:11","modified_gmt":"2024-11-11T20:20:11","slug":"psychiatric-and-neurological-outcomes-in-236379-covid-19-survivors","status":"publish","type":"post","link":"https:\/\/petrusraulino.com.br\/en\/psychiatric-and-neurological-outcomes-in-236379-covid-19-survivors\/","title":{"rendered":"Psychiatric and neurological outcomes in 236,379 COVID-19 survivors"},"content":{"rendered":"

By Dr. Petrus Raulino<\/strong><\/em><\/p>\n

Since the beginning of the COVID-19<\/a> there is growing concern that survivors may be at greater risk of neurological and psychiatric illnesses.<\/span><\/p>\n

An observational study of 62,354 COVID-19 survivors showed an increased risk of mood and anxiety disorders in the first three months after infection. Even among patients without any psychiatric history.\u00a0<\/span><\/p>\n

Over time, new research has contributed to science's further understanding of the evolution of COVID-19.\u00a0<\/span><\/p>\n

Published research has emerged with large-scale data examining the risks of neurological and psychiatric diagnoses after six months of COVID-19 infection.<\/span><\/p>\n

New study on psychiatric condition after COVID-19<\/h2>\n

A recent study carried out at Oxford University and published in the journal <\/span>The Lancet Psychiatry<\/span><\/i> found that one in three people who survive COVID-19 is diagnosed with a neurological or psychiatric condition six months after being infected.<\/span><\/p>\n

To reach this conclusion, the study analyzed the health records of more than 230,000 people with confirmed COVID-19 in 62 healthcare organizations, mainly in the USA.<\/span><\/p>\n

Study results<\/h2>\n

Overall, the estimated incidence of diagnosis of a neurological or psychiatric disorder after COVID-19 infection was 34%. For 13% of these people, it was the first recorded neurological or psychiatric diagnosis.<\/span><\/p>\n

The most common diagnoses after COVID-19 were anxiety disorders (occurring in 17% of patients), mood disorders (14%), substance use disorders (7%) and insomnia (5%).\u00a0<\/span><\/p>\n

The incidence of neurological outcomes was lower, including 0.6% for cerebral hemorrhage, 2.1% for ischemic stroke and 0.7% for dementia.<\/span><\/p>\n

It is worth noting that these incidences were even higher in patients who required hospitalization and markedly higher in those who required ICU admission or developed encephalopathy.<\/span><\/p>\n

Many people wonder how a respiratory illness can cause psychiatric or neurological effects, and the answer to this question is still unclear as to the exact pathophysiological mechanism.<\/span><\/p>\n

However, there are several hypotheses for the potential mechanisms that cause the association between COVID-19 and psychiatric disorders and\/or neurological damage. These include viral invasion of the central nervous system, hypercoagulable states and neural effects of the immune response.\u00a0<\/span><\/p>\n

Conclusion<\/h2>\n

Unfortunately, many of <\/span>psychiatric disorders<\/span> identified by COVID-19 research tend to be chronic or recurrent. Therefore, we can anticipate that the burden of COVID-19 could be with us for many years to come.\u00a0<\/span><\/p>\n

On the other hand, research continues and could also provide us with valuable information on how to deal with or overcome the burden of COVID-19.<\/span><\/p>\n

 <\/p>\n

References<\/strong><\/h4>\n

Lee, M. H., Perl, D. P., Nair, G., Li, W., Maric, D., Murray, H., ... & Nath, A. (2021). Microvascular injury in the brains of patients with Covid-19.\u00a0<\/span>New England Journal of Medicine<\/span><\/i>,\u00a0<\/span>384<\/span><\/i>(5), 481-483.<\/span><\/p>\n

Taquet, M., Luciano, S., Geddes, J. R., & Harrison, P. J. (2021). Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA.\u00a0<\/span>The Lancet Psychiatry<\/span><\/i>,\u00a0<\/span>8<\/span><\/i>(2), 130-140.<\/span><\/p>\n

Taquet, M., Geddes, J. R., Husain, M., & Harrison, P. J. (2021). Six-Month neurological and psychiatric outcomes in 236,379 survivors of COVID-19. <\/span>The Lancet Psychiatry<\/span><\/i>, April 6, published on-line.<\/span><\/p>\n

Kreye, J., Reincke, S. M., & Pr\u00fcss, H. (2020). Do cross-reactive antibodies cause neuropathology in COVID-19?\u00a0<\/span>Nature Reviews Immunology<\/span><\/i>,\u00a0<\/span>20<\/span><\/i>(11), 645-646.<\/span><\/p>\n

Meinhardt, J., Radke, J., Dittmayer, C., Franz, J., Thomas, C., Mothes, R., ... & Heppner, F. L. (2021). Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.\u00a0<\/span>Nature neuroscience<\/span><\/i>,\u00a0<\/span>24<\/span><\/i>(2), 168-175.<\/span><\/p>\n

Rhea, E. M., Logsdon, A. F., Hansen, K. M., Williams, L. M., Reed, M. J., Baumann, K. K., ... & Erickson, M. A. (2021). The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice.\u00a0<\/span>Nature neuroscience<\/span><\/i>,\u00a0<\/span>24<\/span><\/i>(3), 368-378.<\/span><\/p>\n

Panigada, M., Bottino, N., Tagliabue, P., Grasselli, G., Novembrino, C., Chantarangkul, V., ... & Tripodi, A. (2020). Hypercoagulability of COVID<\/span>?<\/span>19 patients in intensive care unit: a report of thromboelastography findings and other parameters of hemostasis.\u00a0<\/span>Journal of Thrombosis and Haemostasis<\/span><\/i>,\u00a0<\/span>18<\/span><\/i>(7), 1738-1742.<\/span><\/p>","protected":false},"excerpt":{"rendered":"

By Dr. Petrus Raulino Since the beginning of the COVID-19 pandemic, there has been growing concern that survivors may be at greater risk of neurological and psychiatric disorders. An observational study of 62,354 COVID-19 survivors showed an increased risk of mood and anxiety disorders in the first three months after infection. 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