{"id":1420,"date":"2021-05-04T16:47:46","date_gmt":"2021-05-04T19:47:46","guid":{"rendered":"https:\/\/petrusraulino.com.br\/?p=1420"},"modified":"2024-11-11T17:20:28","modified_gmt":"2024-11-11T20:20:28","slug":"epigenetic-predictor-of-mortality-and-acceleration-in-major-depressive-disorder","status":"publish","type":"post","link":"https:\/\/petrusraulino.com.br\/en\/epigenetic-predictor-of-mortality-and-acceleration-in-major-depressive-disorder\/","title":{"rendered":"Epigenetic predictor of mortality is accelerated in Major Depressive Disorder"},"content":{"rendered":"

By Dr. Petrus Raulino<\/strong><\/em><\/p>\n

Major Depressive Disorder (MDD) is associated with premature mortality and may represent a state of accelerated cellular aging.<\/p>\n

It is known that MDD is an independent risk factor for a wide range of diseases, especially those associated with ageing, such as cardiovascular disease, diabetes and Alzheimer's.<\/p>\n

In recent years, metrics have been developed to estimate biological age based on DNA methylation patterns.<\/p>\n

But what is DNA methylation?<\/h2>\n

DNA methylation is a mechanism epigenetic<\/a>This means that it causes a change in genetic activity without involving a change in the DNA nucleotide sequence. It involves the transfer of a methyl group to cytosine or adenine.<\/p>\n

DNA methylation regulates gene expression by inhibiting it. It is a dynamic process involving methylation and demethylation in different patterns throughout life.<\/p>\n

The DNA methylation pattern can be seen as a kind of epigenetic \"clock\", as it suggests a biological age in line with its pattern. It is a biomarker of the rate of biological ageing.<\/p>\n

Metrics related to estimating biological age have been used in research to capture accelerated ageing in psychiatric disorders.<\/p>\n

Study on TDM and lifespan<\/h2>\n

In a recent study published in the journal Translational Psychiatry<\/em>Blood samples from individuals with MDD were analyzed for methylation patterns using the GrimAge \"clock\".<\/p>\n

GrimAge is a mathematical algorithm designed to predict an individual's remaining lifespan based on cellular methylation patterns.<\/p>\n

Two groups of individuals were compared: (1) a control group of healthy volunteers and (2) a group of individuals with moderate to severe MDD who were somatically healthy and not medicated.<\/p>\n

The MDD group showed a significantly higher GrimAge score in relation to their chronological age compared to healthy individuals of the same chronological age - an average of approximately two years more on the GrimAge \"clock\".<\/p>\n

These findings show a new perspective on the increased morbidity and mortality associated with MDD, suggesting that there may be an underlying biological mechanism that accelerates cellular aging in some MDD sufferers.<\/p>\n

Further research is needed to increase understanding of the findings and to assess the influence of TDM treatments on the cellular ageing process.<\/p>\n

 <\/p>\n

References<\/strong><\/h4>\n

Protsenko, E., Yang, R., Nier, B., Reus, V., Hammamieh, R., Rampersaud, R., ... & Wolkowitz, O. M. (2021). \"GrimAge,\" an epigenetic predictor of mortality, is accelerated in major depressive disorder. Translational psychiatry, 11(1), 1-9.<\/p>\n

Lu, A. T., Quach, A., Wilson, J. G., Reiner, A. P., Aviv, A., Raj, K., ... & Horvath, S. (2019). DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging (Albany NY), 11(2), 303.<\/p>\n

Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., ... & Rakyan, V. K. (2019). DNA methylation aging clocks: challenges and recommendations. Genome biology, 20(1), 1-24.<\/p>\n

Horvath, S., & Raj, K. (2018). DNA methylation-based biomarkers and the epigenetic clock theory of aging. Nature Reviews Genetics, 19(6), 371-384.<\/p>\n

Wu, T. P., Wang, T., Seetin, M. G., Lai, Y., Zhu, S., Lin, K., ... & Xiao, A. Z. (2016). DNA methylation on N 6-adenine in mammalian embryonic stem cells. Nature, 532(7599), 329-333.<\/p>\n

Hannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G., Sadda, S., ... & Zhang, K. (2013). Genome-wide methylation profiles reveal quantitative views of human aging rates. Molecular Cell, 49(2), 359-367.<\/p>\n

Moore, L. D., Le, T., & Fan, G. (2013). DNA methylation and its basic function. Neuropsychopharmacology, 38(1), 23-38.<\/p>","protected":false},"excerpt":{"rendered":"

By Dr. Petrus Raulino Major Depressive Disorder (MDD) is associated with premature mortality and may represent a state of accelerated cellular aging. MDD is known to be an independent risk factor for a wide range of diseases, especially those associated with ageing, such as cardiovascular disease, diabetes and Alzheimer's disease. Over the last few years, [...]<\/p>","protected":false},"author":4,"featured_media":1432,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_joinchat":[],"footnotes":""},"categories":[115,121,1,117],"tags":[],"class_list":["post-1420","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informativo","category-saude-mental","category-sem-categoria","category-transtornos-psicologicos"],"yoast_head":"\nPreditor epigen\u00e9tico mortalidade \u00e9 acelerado no t. depressivo maior<\/title>\n<meta name=\"description\" content=\"O Transtorno Depressivo Maior (TDM) est\u00e1 associado \u00e0 mortalidade prematura e pode representar um estado de envelhecimento celular acelerado.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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