{"id":1333,"date":"2021-04-05T16:17:13","date_gmt":"2021-04-05T19:17:13","guid":{"rendered":"https:\/\/petrusraulino.com.br\/?p=1333"},"modified":"2024-11-11T17:24:09","modified_gmt":"2024-11-11T20:24:09","slug":"antidepressants-reduce-the-risk-of-intubation-or-death-in-patients-hospitalized-with-covid-19","status":"publish","type":"post","link":"https:\/\/petrusraulino.com.br\/en\/antidepressants-reduce-the-risk-of-intubation-or-death-in-patients-hospitalized-with-covid-19\/","title":{"rendered":"Do antidepressants reduce the risk of intubation or death in COVID patients?"},"content":{"rendered":"

By Dr. Petrus Raulino<\/strong><\/em><\/p>\n

The answer to this question is not definitive, nor should the use of antidepressants be encouraged. This class of medication should only be used if indicated by a doctor after careful evaluation.<\/p>\n

 <\/p>\n

Study on the use of antidepressants for COVID-19<\/h2>\n

That said, a study published in the journal Molecular Psychiatry showed an association between the use of antidepressants and a reduced risk of intubation or death among adult patients admitted with COVID-19<\/a>.<\/p>\n

This multicenter retrospective observational study included data on all adult COVID-19 patients admitted to any of the 39 AP-HP hospitals of the Greater University of Paris at the start of the pandemic.<\/p>\n

Antidepressant use was defined as receiving any antidepressant during the first 48 hours of hospital admission and before the end of hospitalization, intubation or death.<\/p>\n

 <\/p>\n

Study results<\/h3>\n

Despite the study's limitations, it showed that the use of antidepressants in usual doses was associated with a substantial reduction in the risk of intubation or death in patients hospitalized with COVID-19.<\/p>\n

Although the finding is relevant, statistical biases can occur, which is why new studies are needed. In particular, double-blind randomized controlled clinical trials are important to inform changes in medical treatments.<\/p>\n

The association observed between the use of antidepressants and a reduced risk of intubation or death, if proven, could be explained by various mechanisms, according to the study's authors.<\/p>\n

    \n
  1. Firstly, previous studies suggest that various antidepressants can inhibit the activity of acid sphingomyelinase, which can prevent the infection of epithelial cells against SARS-CoV-2.<\/li>\n
  2. Secondly, several antidepressants are sigma-1 receptor agonists, which can prevent the cytokine storm seen in severe COVID-19.<\/li>\n
  3. Thirdly, the use of antidepressants may be associated with reduced plasma levels of several inflammatory mediators associated with severe COVID-19, including IL-6, IL-10, TNF-? and CCL-2.<\/li>\n
  4. Finally, certain antidepressants can potentially exert antiviral effects on SARS-CoV-2.<\/li>\n<\/ol>\n

     <\/p>\n

    Conclusion<\/h2>\n

    If the association between antidepressant use and reduced risk of intubation or death from COVID-19 is confirmed in research that determines efficacy, further studies will still be needed to determine the exact mechanisms underlying this association.<\/p>\n

    For the time being, the above findings and hypotheses are not definitive, but they do provide a stimulus for further research. We're keeping an eye on things.<\/p>\n

     <\/p>\n

     <\/p>\n

    References<\/h6>\n

    Hoertel, N., S\u00e1nchez-Rico, M., Vernet, R., Beeker, N., Jannot, A. S., Neuraz, A., ... & Limosin, F. (2021). Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study. Molecular psychiatry, 1-14.<\/p>\n

    Carpenter, A., Edwards, M. J., Hoffmann, M., Kochs, G., Gripp, B., Weigang, S., ... & Gulbins, E. (2020). Pharmacological inhibition of acid sphingomyelinase prevents uptake of SARS-CoV-2 by epithelial cells. Cell Reports Medicine, 1(8), 100142.<\/p>\n

    Lenze, E. J., Mattar, C., Zorumski, C. F., Stevens, A., Schweiger, J., Nicol, G. E., ... & Reiersen, A. M. (2020). Fluvoxamine vs placebo and clinical deterioration in outpatients with symptomatic COVID-19: a randomized clinical trial. JAMA, 324(22), 2292-2300.<\/p>\n

    Gordon, D. E., Jang, G. M., Bouhaddou, M., Xu, J., Obernier, K., White, K. M., ... & Krogan, N. J. (2020). A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature, 583(7816), 459-468.<\/p>\n

    Hojyo, S., Uchida, M., Tanaka, K., Hasebe, R., Tanaka, Y., Murakami, M., & Hirano, T. (2020). How COVID-19 induces cytokine storm with high mortality. Inflammation and Regeneration, 40(1), 1-7.<\/p>\n

    K\u00f6hler, C. A., Freitas, T. H., Stubbs, B., Maes, M., Solmi, M., Veronese, N., ... & Carvalho, A. F. (2018). Peripheral alterations in cytokine and chemokine levels after antidepressant drug treatment for major depressive disorder: systematic review and meta-analysis. Molecular neurobiology, 55(5), 4195-4206.<\/p>\n

    Zimniak, M., Kirschner, L., Hilpert, H., Seibel, J., & Bodem, J. (2020). The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2. Biorxiv.<\/p>\n

    Gulbins, E., Palmada, M., Reichel, M., L\u00fcth, A., B\u00f6hmer, C., Amato, D., ... & Kornhuber, J. (2013). Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. Nature medicine, 19(7), 934-938.<\/p>","protected":false},"excerpt":{"rendered":"

    By Dr. Petrus Raulino The answer to the question is not definitive, nor should the use of antidepressants be encouraged. This class of medication should only be used if indicated by a doctor after careful evaluation. Study on the use of antidepressants for COVID-19 That said, a study published in the journal Molecular Psychiatry showed [...]<\/p>","protected":false},"author":4,"featured_media":1362,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_joinchat":[],"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1333","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sem-categoria"],"yoast_head":"\nAntidepressivos reduzem risco de morte pacientes com COVID?<\/title>\n<meta name=\"description\" content=\"A resposta \u00e0 quest\u00e3o n\u00e3o \u00e9 definitiva, e nem se deve estimular o uso de antidepressivos. Essa medica\u00e7\u00e3o s\u00f3 deve ser usada se indicada.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/petrusraulino.com.br\/en\/antidepressants-reduce-the-risk-of-intubation-or-death-in-patients-hospitalized-with-covid-19\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antidepressivos reduzem o risco de intuba\u00e7\u00e3o ou morte em pacientes com COVID?\" \/>\n<meta property=\"og:description\" content=\"A resposta \u00e0 quest\u00e3o n\u00e3o \u00e9 definitiva, e nem se deve estimular o uso de antidepressivos. Essa medica\u00e7\u00e3o s\u00f3 deve ser usada se indicada.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/petrusraulino.com.br\/en\/antidepressants-reduce-the-risk-of-intubation-or-death-in-patients-hospitalized-with-covid-19\/\" \/>\n<meta property=\"og:site_name\" content=\"Dr. Petrus Raulino\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/drpetrusraulinopsiquiatriaclinica\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-05T19:17:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-11T20:24:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/petrusraulino.com.br\/wp-content\/uploads\/2021\/04\/0Antidepressivos-reduzem-o-risco-de-intuba\u00e7\u00e3o-e-morte.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1447\" \/>\n\t<meta property=\"og:image:height\" content=\"882\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Dr. Petrus Raulino\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Dr. Petrus Raulino\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Do antidepressants reduce the risk of death in COVID patients?","description":"The answer to this question is not definitive, nor should the use of antidepressants be encouraged. This medication should only be used if indicated.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/petrusraulino.com.br\/en\/antidepressants-reduce-the-risk-of-intubation-or-death-in-patients-hospitalized-with-covid-19\/","og_locale":"en_US","og_type":"article","og_title":"Antidepressivos reduzem o risco de intuba\u00e7\u00e3o ou morte em pacientes com COVID?","og_description":"A resposta \u00e0 quest\u00e3o n\u00e3o \u00e9 definitiva, e nem se deve estimular o uso de antidepressivos. Essa medica\u00e7\u00e3o s\u00f3 deve ser usada se indicada.","og_url":"https:\/\/petrusraulino.com.br\/en\/antidepressants-reduce-the-risk-of-intubation-or-death-in-patients-hospitalized-with-covid-19\/","og_site_name":"Dr. Petrus Raulino","article_publisher":"https:\/\/www.facebook.com\/drpetrusraulinopsiquiatriaclinica","article_published_time":"2021-04-05T19:17:13+00:00","article_modified_time":"2024-11-11T20:24:09+00:00","og_image":[{"width":1447,"height":882,"url":"https:\/\/petrusraulino.com.br\/wp-content\/uploads\/2021\/04\/0Antidepressivos-reduzem-o-risco-de-intuba\u00e7\u00e3o-e-morte.jpg","type":"image\/jpeg"}],"author":"Dr. Petrus Raulino","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Dr. Petrus Raulino","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[]}},"_links":{"self":[{"href":"https:\/\/petrusraulino.com.br\/en\/wp-json\/wp\/v2\/posts\/1333","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/petrusraulino.com.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/petrusraulino.com.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/petrusraulino.com.br\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/petrusraulino.com.br\/en\/wp-json\/wp\/v2\/comments?post=1333"}],"version-history":[{"count":1,"href":"https:\/\/petrusraulino.com.br\/en\/wp-json\/wp\/v2\/posts\/1333\/revisions"}],"predecessor-version":[{"id":45277,"href":"https:\/\/petrusraulino.com.br\/en\/wp-json\/wp\/v2\/posts\/1333\/revisions\/45277"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/petrusraulino.com.br\/en\/wp-json\/wp\/v2\/media\/1362"}],"wp:attachment":[{"href":"https:\/\/petrusraulino.com.br\/en\/wp-json\/wp\/v2\/media?parent=1333"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/petrusraulino.com.br\/en\/wp-json\/wp\/v2\/categories?post=1333"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/petrusraulino.com.br\/en\/wp-json\/wp\/v2\/tags?post=1333"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}